Nanocurcumin, Promising Potential Protective Agent Against Histopathological Damage in the Cerebral Cortex of Mice Induced by Aluminum Chloride

Yulia Irnidayanti, Fudchus Tifany Nabilah and Nina Herlina

Background and Objective: Aluminum (Al) is widely used in many aspects of daily life, such as food packaging, cooking utensil components, food additives, cosmetics and water distillation. This study aimed to evaluate the protective role of nanocurcumin on the cerebral cortex of one and two-month-old mice exposed to 200 mg kg^–1 b.wt., aluminium. Materials and Methods: The Swiss Webster mice were used in this study. The control group only received sterile distilled water, the Al group was administered 200 mg kg^–1 b.wt., of AlCl₃ solution and the Al+Na Cur group was administered 200 mg kg^–1 b.wt., AlCl₃+200 mg kg^–1 nanocurcumin by intraperitoneal injection. The nanocurcumin was administered one hour after AlCl₃ exposure and then on days 0, 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30. All the mice were anaesthetized and their brains were collected and fixed in a neutral formalin buffer solution for histological analysis. The paraffin method was used in this study. Results: The death of granular neuron cells and karyolysis cells and the vacuolation of the pyramid cell layer of the cerebral cortex could be prevented by the intraperitoneal administration of nanocurcumin. The effect of nanocurcumin administration on the Al group at two months of age was more effective than on the Al group at one month of age. Conclusion: Nanocurcumin can be a promising candidate protective agent against cerebral cortex changes after aluminium administration.

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