Comparative Toxicity Study of Novel Light-Activated Insecticide and Deltamethrin in Albino Rats

Mohamed Abd Elfattah Noaishi, Nashwah Kamal Abd Elfattah and Tarek Abd Allah El-Tayeb

Background and Objective: Tri-sodium Copper of chlorophyllins (Agri-Safe) is a novel biocide using recently to control the mosquitoes as a larvicide. Because, the lack of adequate data on the toxicity of this compound, more toxicological studies on this new compound are necessary. Therefore the study aimed to evaluate the adverse effects of this new insecticide and in comparison with the traditional insecticide Deltamethrin (DM). Materials and Methods: Twenty-five adult male rats were randomly divided into five groups. The first group was kept in control. The second and third groups were administered at doses of 0.59 and 0.24 mg kg^–1 b.wt., of DM. The fourth and 5th groups were administrated at doses of 250 and 100 mg kg^–1 b.wt. of Agri-Safe respectively. The administrations were orally by gavage for 90 consecutive days. The rats were humanly sacrificed and whole blood was collected for hematological parameters and bone marrow was collected for mutagenicity assays. Results: The estimated LD₅₀ of DM and Agri-Safe were 11.76 and more than 5000 mg kg^–1 b.wt., respectively. Both insecticides induced slight hepatotoxicity but not nephrotoxicity. The high and low doses of DM induced prominent oxidative stress while Agri-Safe did not induce oxidative stress. The results of genotoxicity revealed that DM caused greater mutagenic effect at high and low doses, while Agri-Safe induced slight significant genotoxicity at high-dose only. Conclusion: It can be concluded that Deltamethrin (DM) can induce oxidative stress and prominent genotoxicity while tri-sodium copper of chlorophyllins has a low side effect and its effect is due to copper elements.

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