Assessment of Wound Healing Potentials of Methanol Extract of Anthocleista vogelii Leaves on Female Wistar Rats

Onyinye Acha, Joyce Akaninwor, Charity Ogunka-Nnoka and Precious Ogamba

Background and Objective: Conventional drugs used in wound treatment are not only expensive but also have challenges of allergies and drug resistance. This necessitates the need to seek alternatives, especially in the area of medicinal plants which is still not fully explored. In this article wound healing potentials of methanol extract of Anthocleista vogelii leaves were studied. Materials and Methods: The 25 female Wistar rat (144-176 g) were divided into 5 groups of 5 rats each. Group 1 (normal control), group 2 and 3 were topically administered 0.1 g of Vaseline and 0.1 g Gentamicin, while groups 4 and 5 were administered 0.1 g Vaseline along with 0.1g extract (A. vogelii 1) and 0.2 g extract (A. vogelii 2), respectively for 14 days after inducing excision wound (2 cm) on the dorsal skin. An assay for biochemical and wound healing parameters was carried out using standard methods. Results: Wound healing studies revealed a significant increase in oestrogen level in group 4 and a significant decrease in iron level in group 5 when compared with group 1, 2 and 3. Hematological results revealed an increase in PCV, Hb, RBC, Platelets and RBC, WBC, neutrophil, eosinophil and monocyte on administration of Anthocleista vogelii leaves. Conclusion: The study thus revealed that Anthocleista vogelii leaves possess wound healing potential.

View Fulltext Back