Protective Effect of Olive Leaves Extract in Male Rats after the Administration of Cimetidine

Asmaa Khalid Mohammed, Omar Ibrahim and Dakheel Hadri

Background and Objective: Cimetidine is a drug used in the treatment of ulcers in a wide range put have highly harms the male reproductive system. This study was undertaken to determine the protective effects of the administration of olive leaves extract (OLE) on male rats after the administration of cimetidine. Materials and Methods: In this investigation, 30 male rats were randomly classified into three groups, the control group (G1): Receiving normal saline, the cimetidine group (G2): Receiving 100 mg kg^–1 b.wt., of cimetidine and the third group (G3) contain cimetidine (100 mg kg^–1 b.wt.)+olive leaves extract (500 mg kg^–1 b.wt.) orally for 38 days from 20 November, 2022 to 28 December, 2022. After completing the study, the animal was slaughtered and the testis was analyzed histologically. Results: The cimetidine group showed a significant decrease in body weight and testicular weight compared to the control group a significant decrease in semen parameters and also a significant decrease in sex hormones and antioxidant markers. However after treatment with the cimetidine+OLE group detected a significant increase in body and testicular weight, semen parameters, sex hormones and antioxidant markers compared to the cimetidine group. Conclusion: The OLE has a significant protective effect from cimetidine toxicity on the male reproductive system.

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