Senna occidentalis Leaf Extracts Ameliorate Biochemical Parameters of Diabetic Nephropathy in Diabetic Wistar Rats

Rasheed Ibrahim, Mutiu Alabi, Babalola Yusuf, Latifat Ibrahim, Jamiu Ahmad, Kehinde Ogunyale, Esther Oladiji and Rihanat Bashir

Background and Objective: Senna occidentalis is widely used in the folkloric treatment and management of various diseases. Its therapeutic benefit for diabetic kidney disease however remains unexplored. This study evaluated the effects of leaf phenolic and alkaloid extracts of Senna occidentalis on biomarkers of diabetic nephropathy in diabetic Wistar rats. Materials and Methods: Forty-two male Wistar rats were grouped into seven groups of six animals each. Experimental diabetes was induced in all rats except group 1, control. Groups 2-7 were orally administered 1mL of distilled water, 14.3 mg kg^–1 b.wt., metformin, 100 and 200 mg kg^–1 b.wt., phenolics (SOLPE) and alkaloid (SOLAE) extracts of Senna occidentalis leaf respectively for 14 days. Data were analyzed by one-way analysis of variance followed by Tukey-post hoc test for multiple comparisons among means of five replicates at p<0.05 using GraphPad Prism version 6. Results: The results showed that the serum concentrations of uric acid, urea, cystatin C, creatinine, the renal concentration of tumour necrosis factor-α and malondialdehyde and parameters of oxidative stress which were compromised in the diabetic untreated rats were significantly reversed on treatment with SOLPE and SOLAE at 100 and 200 mg kg^–1 b.wt. Conclusion: Thus, phenolic and alkaloid extracts of Senna occidentalis leaf possess ameliorative effects on the parameters of diabetic nephropathy in high-fat-diet/streptozotocin-induced diabetic rats and can be explored for the management of diabetic kidney disease.

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