Antihyperglycemic Potential of Methanolic Extracts from the Medicinal Plants: Marrubium deserti De Noé and Marrubium vulgare L.

Nabil Ghedadba, Leila Hambaba, Massoud Hachemi, Mohamed Bensaad, Saliha Dassamiour, Rokayya Sami, Garsa Alshehry, Zayed Alsharari, Dania Waggas, Naseh Algehainy, Essra Noorwali, Awatif Almehmadi, Suzan Abushal, Rasha Al-Eisa, Fayez Althobaiti and Nehad Shaer

Background and Objective: Plants of the genus Marrubium are used to cure several infectious diseases like asthma, rheumatoid and diabetes. This study investigated in vivo antihyperglycemic capacity of the methanolic fraction (MeOHE) of two Marrubium species via animal model. Materials and Methods: The plant extracts were investigated both qualitatively and quantitatively to reveal their phytochemical composition. Pharmacologically speaking, Wistar albino rats of either sex (150-180 g) were used to investigate the antidiabetic effect using 25 rats in each of the two used approaches; respectively Oral Glucose Tolerance Test (OGTT) and streptozotocin-induced diabetes approaches. In addition, various biochemical parameters were investigated to confirm the pharmacological quality of our plants. Evaluated for their possible antidiabetic effect during two consecutive weeks for glycemia levels (2 hrs period). Results: Data revealed that MeOHE induced a significant antihyperglycemic effect, in which M. deserti, a slight decrease in the glucose level at (143±0.5 mg/dL) was obtained while a reduction was recorded for M. vulgare (71.5±0.75 mg/dL) with a same observation for triglycerides, cholesterol, glutamic-oxaloacetic transaminase (TGO), glutamic pyruvic transaminase (TGP), creatinine comparing to standard. Moreover, the result showed high levels of phenolic and flavonoïds content. Conclusion: This modest work confirmed once again the real pharmacological capacity of vegetals and their possible implication to cure diabetes and complications related to it underlying the antihyperglycemic activity of these plants.

View Fulltext Back