International Journal of Pharmacology

Volume 20 (8), 1448-1456, 2024


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Efficacy of 2-Chloro-3-Hydrazinylquinoxaline in Alleviating Indomethacin-Induced Gastric Ulcers: Insights from Animal Model Investigation

Yousef Almoghrabi, Hussam Daghistani, Taghreed Shamrani, Motasim Jawi, Samah Labban, Hanouf Niyazi, Hatoon Niyazi, Noof Helmi, Hind AbdulMajed, Noha Juma, Tariq Ekhmimi, Bandar Saleh, Karem Ibrahem and Abdelbagi Alfadil

Background and Objective: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are widely used for pain and inflammation relief but are associated with remarkable risk, notably gastric damage. This damage substantially contributes to the development of stomach ulcers, a leading cause of morbidity. The current study investigated the gastroprotective effects of 2-Chloro-3-hydrazinylquinoxaline in a rat model of indomethacin-induced gastric. Materials and Methods: Thirty male Wistar rats were divided into five groups: Control, indomethacin only, indomethacin with varying doses of 2-Chloro-3-hydrazinylquinoxaline and indomethacin with Esomeprazole. The efficacy of 2-Chloro-3-hydrazinylquinoxaline in mitigating gastric ulcers was assessed through histopathological examinations and the measurement of inflammatory biomarkers. A one-way ANOVA was used for multiple comparisons, followed by Tukey’s post-hoc test. Results: Indomethacin-induced ulcers resulted in notable epithelial damage and blood streaks on the gastric mucosa. In contrast, treatment with 2-Chloro-3-hydrazinylquinoxaline significantly (p<0.05) reduced ulcer formation compared to the indomethacin-only group. The 2-Chloro-3-hydrazinylquinoxaline-treated group exhibited restoration of normal epithelial tissue and minimal presence of inflammatory cells, findings that were comparable to those in the control and Esomeprazole-treated groups. Additionally, 2-Chloro-3-hydrazinylquinoxaline significantly (p<0.05) decreased inflammatory biomarkers while enhancing levels of gastroprotective mediator compared to indomethacin alone. Conclusion: These findings highlight the gastroprotective properties of 2-Chloro-3-hydrazinylquinoxaline, demonstrating its potential efficacy in treating NSAID-induced gastric ulcers.

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How to cite this article:

Yousef Almoghrabi, Hussam Daghistani, Taghreed Shamrani, Motasim Jawi, Samah Labban, Hanouf Niyazi, Hatoon Niyazi, Noof Helmi, Hind AbdulMajed, Noha Juma, Tariq Ekhmimi, Bandar Saleh, Karem Ibrahem and Abdelbagi Alfadil, 2024. Efficacy of 2-Chloro-3-Hydrazinylquinoxaline in Alleviating Indomethacin-Induced Gastric Ulcers: Insights from Animal Model Investigation. International Journal of Pharmacology, 20: 1448-1456.


DOI: 10.3923/ijp.2024.1448.1456
URL: https://ansinet.com/abstract.php?doi=ijp.2024.1448.1456

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