Correlation of Folic Acid Metabolism Gene Polymorphism with Maternal Delivery Outcomes and Neonatal Congenital Diseases During Pregnancy

Wei Liu, Jiehong Li, Jing Wang, Yeqing Su and Yachai Li

Background and Objective: Folic acid (FA) plays a vital part in pregnancy. This study analyzes the correlation of FA metabolism gene polymorphism with maternal delivery outcomes to provide reliable guidance for pregnant women. Materials and Methods: TaqMan-MGB was used to detect the C677T and A1298C loci of FA metabolism gene MTHFR and A66G locus of MTRR. The correlations of FA risk levels and metabolic gene polymorphism with adverse events (AEs) during pregnancy and final birth outcomes were discussed. Results: Significant differences were observed in the risk levels of FA disorders between normal pregnant women and those with oligohydramnios (OH), gestational diabetes mellitus (GDM) or gestational hypertension (GH), same results between pregnant women with the termination of pregnancy, premature birth, dystocia and congenital diseases in the newborn and those with normal delivery, the genotype of MTHFR C677T, MTHFR A1298C and MTRR A66G showed no difference, but the allele of MTHFR C677T differed evidently. Significant differences were also present in the risk levels of FA disorders. Conclusion: The risk levels of FA metabolism disorders are strongly related to AEs during pregnancy and adverse pregnancy outcomes.

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