Ahmed H. Mujamammi, Essa M.Sabi, Ziyad M. Althafar, Khalid M. Sumaily and Lotfi S. Bin Dahman

Background and Objective: The global prevalence of diabetes mellitus is alarmingly rising. Diabetes mellitus has multi-systemic complications. One of the widespread complications is diabetic nephropathy, where patients have a progressive decline in renal function chiefly due to oxidative stress. The current study aims to counteract oxidative stress and explored the nephroprotective potential of Crataegus oxyacantha extracts in streptozotocin-induced diabetic nephropathy in Zebrafish Model. Materials and Methods: Intraperitoneal administration of STZ induced diabetic nephropathy in the Zebrafish Model. The hydroalcoholic Crataegus oxyacantha extract was supplemented and its activity was assessed by measuring blood parameters (blood glucose, serum urea and serum creatinine), kidney antioxidant enzyme and oxidative stress levels (GST, GSH, SOD and TBARS) and the kidney histology. Results: The supplementation of the plant extract successfully alleviated hypoglycemia and serum urea and creatinine levels. It also enhanced the activity of powerful antioxidants and reduced stress levels. The histological section of the kidney showed restoration of deregulated structure and anti-inflammatory effects. Conclusion: It was evident that the antidiabetic, nephroprotective and anti-inflammatory properties were attributed to the hydroalcoholic extracts of Crataegus oxyacantha.

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