Potential Effects of Oligofructose-Enriched Inulin Macromolecules (Prebiotin^TM) on an Ovariectomy-Induced Osteoporotic Rat Model

Alshimaa A. Abd-Elmoneam, Nada A. Koheil, Maher A. Kamel and Galila Yacout

Background and Objective: Osteoporosis is the most common disease, particularly among old-age women. This study aims to examine the potential role of Prebiotin^TM macromolecule on the treatment of osteoporotic female rats induced by ovariectomy and compare its effect with estradiol benzoate drug. Materials and Methods: A total of 50 g Prebiotin^TM/kg diet/day was added to an experimental ovariectomy female rat diet and estradiol benzoate drug was injected subcutaneously to another osteoporotic group at a dose of 30 g kg^–1 b.wt. Bone mineral density, bone mineral content and bone ash mineral contents were estimated for the examined rats. Also, serum ALP, RANKL, OPG and osteocalcin levels were determined. Moreover, histopathological, body and uterus weight alterations were detected among different studied groups. Results: Supplementing an ovariectomized rat model with Prebiotin^TM could significantly restore the reduced minerals absorption, bone mineral contents and densities, bone histological features and bone chemical composition, with a simultaneous increase in serum OPG level and decrease in serum RANKL, ALP and osteocalcin levels that resulted in regaining the balance of bone remodelling and turnover process. Conclusion: Prebiotin^TM was a safe agent that had a therapeutic capacity against ovariectomy-induced osteoporosis in a female rat model and can be used as an adjunct for calcium supplementation to reduce bone loss in old age people.

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