Effect and Mechanism of Reduning Injection on Respiratory Syncytial Virus (RSV)-Induced Airway Inflammation in Mice

Zhi Shang and Haoyu Xing

Background and Objective: Respiratory Syncytial Virus (RSV) can cause severe pneumonia and bronchiolitis, leading to symptoms such as wheezing and dyspnea and inducing heart failure in severe cases. Reduning injection demonstrates notable efficacy in treating conditions like influenza, acute bronchitis, respiratory infections and cough resulting from an invasion of external wind-heat factors. To explore the effect of Reduning injection on the Respiratory Syncytial Virus (RSV)-induced airway inflammation in mice and analyze its mechanism of action. Materials and Methods: Thirty mice were divided into a control group, a model group and Reduning group according to the random number table method, with 10 mice in each group. The model group and Reduning group were given nasal dripping of the RSV virus to establish an RSV infection model and the blank control group received nasal dripping of an equal amount of normal saline. After successful modeling, 0.2 mL/kg of Reduning injection was intraperitoneally injected in the Reduning group and an equal amount of normal saline was given intraperitoneally in the control group and model group and the treatment was continuous for 7 consecutive days. Results: Compared with the model group, the Reduning group displayed higher levels of IL-2 and IFN-γ but lower levels of IL-6, IL-17 and IL-23 (p<0.05); when compared with the model group, the Reduning group showed lower levels of MDA and NO but higher levels of SOD (p<0.05). Conclusion: Reduning injection can effectively reduce RSV-induced airway inflammation and improve immune function in mice and its mechanism of action may be related to the inhibition of oxidative stress and the regulation of JAK1, STAT6 and NGF protein expression.

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