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Asian Journal of Clinical Nutrition
eISSN: 2077-2033
pISSN: 1992-1470

Editor-in-Chief:  Mahomoodally Mohamad Fawzi
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Research Article
Published on April 11, 2018
Chemical Composition and Ameliorative Effect of Tomato on Isoproterenol-induced Myocardial Infarction in Rats
Amnah Mohammed Abdulrahman Alsuhaibani
Background and Objective: Tomatoes are rich in active components, such as polyphenols and carotenoids. This study investigated the chemical composition of tomato fruit and the ability of fruits and their pomace (peel, pulp and seeds) to protect against isoproterenol-induced myocardial infarction in rats. Materials and Methods: The proximate chemical composition and the concentrations of some minerals (Ca, Fe, Zn and K), vitamins (C, A, B1, B2 and B6) and antioxidants (β-carotene, lycopene and total phenolic compounds) were estimated in tomato fruits. About 40 rats were injected subcutaneously with isoproterenol dissolved in normal saline at the dose of 100 mg kg–1 daily for 3 consecutive days to induce acute myocardial infarction. Then, rats were classified into the untreated group (positive control) and four treated groups (tomato peel, seed, pulp and whole fruit). Results: The tomato fruits were rich in carbohydrate, protein and fiber but contained little lipid. Phenolic compounds, vitamin C, lycopene, vitamin A and calcium were detected. Compared to the control group, rats fed tomato peel, seeds, pulp and whole fruit had significantly increased body weight gain and food efficiency ratio. Compared to the control group, the tomato-fed groups had decreased total cholesterol, triglycerides and low- and very low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol. A decrease in serum liver enzyme activity and an increase in antioxidant enzymes in the tomato-fed rats were detected. Conclusion: Administration of tomato and its components has protective effects against isoproterenol-induced myocardial infarction in rats.
Research Article
Hypoglycemic Effect of Analog Rice Made from Modified Cassava Flour (Mocaf), Arrowroot Flour and Kidney Bean Flour on STZ-NA Induced Diabetic Rats
Sri Budi Wahjuningsih, Haslina , Sri Untari and Agus Wijanarka
Background and Objective: Analog rice made from modified cassava flour (mocaf), arrowroot and kidney beans contains high level of dietary fiber and resistant starch potentially consumed as functional food, particularly for diabetes mellitus. However, its hypoglycemic property has not been comprehensively investigated. After previous research on analog rice made from mocaf and kidney beans flour as protein source, arrowroot flour was added to the formulation due to its hypoglycemic effect. The aim of the study was to evaluate hypoglycemic effect of analog rice made from mocaf, arrow root and kidney beans on Streptozotocin-Nicotinamide (STZ-NA) induced diabetic rats. Materials and Methods: Twenty four male Wistar rats were randomly divided into 4 groups, 6 rats each, healthy rats fed with standard feed (H) and three diabetic groups, respectively fed with standard feed (DM), rice variety C4 and mocaf, arrowroot and kidney beans based analog rice (AR). Results: During 4 weeks intervention, feed consumption, body weight and blood glucose level were measured once a week. The results indicated that diabetic rats fed with analog rice (AR)had the highest blood glucose level reduction (55.07%), significantly higher than C4 (18.91%). Total Short Chain Fatty Acids (SCFA) concentration of groups fed with analog rice and rice was 53.96 and 50.76 mmol L–1, respectively. AR group also had higher Langerhans islets of 10.60 than C4 group of 6.80. The analog rice treatment decreased the blood glucose level. Conclusion: The results indicated that RS and dietary fiber was responsible to glucose reduction effect by analog rice diet through SCFA as resistant starch fermentation product in colon.
Research Article
Association Between Major Dietary Patterns and Grades of Knee Osteoarthritis in Women
Afsoun Abdollahi, Masoomeh Hajizadehoghaz, Reza Mohseni, Sima Aliakbar, Zahra Veisy, Mir Saeed Yekaninejad, Zhila Maghbooli and Khadijeh Mirzaei
Background and Objective: Osteoarthritis (OA) is the most common progressive joint disease considered as an inflammatory disease in the elderly and one of the main causes of physical disabilities. Limited studies have assessed the relationship between dietary patterns and knee OA. The Objective of the study was to investigate the relationship between major dietary patterns and different degrees of knee Osteoarthritis (OA) based on Kellgren and Lawrence (K and L) score in a group of Tehranian women. Materials and Methods: In this cross-sectional study, data of 231 patients was diagnosed with different grades of knee OA (age: 52.59±7.69 years). Also, anthropometric measurements and blood samples were collected in order to determine fasting blood sugar (FBS), lipid profile, hs-CRP, ALT and AST. Physical activity and food intakes information were gathered by physical activity and a semi-quantitative food frequency questionnaire (SFFQ) with 147 items. Finally, three major dietary patterns were derived from Principle Component Analysis. Results: Three major dietary patterns were extracted, "Western", "Traditional" and "Healthy". Western dietary pattern (WDP) contains high intake of junk foods, sweets-dessert-high calorie beverages, processed food, coffee and high fat dairy and low intake of fruits and vegetables. Traditional dietary pattern (TDP) characterized by high intake of red meats, organ meats, legumes, onion and potato, olive, eggs and nuts. Also, healthy dietary pattern (HDP) contains high intake of liquid oil, low fat dairy, unrefined grains, white meats and tea. Overall, total variance of the three dietary patterns accounted for 25.8%. In comparison to all patients in the lower tertile, women in the 3rd tertile of WDP were younger and less physically active. Lower physical activity, higher basal metabolic rates and fat free mass variables were observed in the 3rd tertile of the HDP (p<0.05). Among 61.5% of participants who were postmenopausal women (after stratifying based on menopausal status), participants in the higher tertile of TDP predisposed to severe degrees of knee OA (OR: 2.178, 95% CI 1.084-4.374). Conclusion: It is concluded that postmenopausal women with higher adherence to Iranian TDP in comparison to lower tertile of this dietary pattern may prone to knee OA more than two fold, due to inflammatory food groups.

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