Inhibiting Effect of Medical Compounds for SARS-CoV-2 and Secretory Phospholipase A2

Faik Gökalp

Background and Objective: New research about COVID-19 disease is emerging every day. The sPLA2 group IIA (sPLA2-IIA) enzyme, produced for the metabolic elimination of this virus is detected in the blood of COVID-19 patients. An excessive amount in the body will lead to multi-organ failure. The aim of this study was to investigate the inhibitory effect of the main natural active compounds found in medicinal plants on the sPLA2 group IIA (sPLA2-IIA) enzyme, COVID-19 and ACE2. Materials and Methods: The inhibition effects of active compounds (thymol, carvacrol, piperine, cucurbitacin-E and cucurbitacin-I) in some herbal products (oregano, black pepper and Ecballium elaterium L.) used medicinally in daily life on COVID-19 virus, ACE2-linked SARS-CoV-2 spike receptor and sPLA2 group IIA (sPLA2-IIA) enzyme will be calculated by using chemical calculation method and computational theoretical methods. Results: According to the data obtained from the docking energy scores of the chemical calculation method of piperine, one of the natural active substances investigated, it is seen that its inhibitory effect is quite good compared to other active compounds. It is understood that the natural active compounds determined as ligands here are quite effective on both SARS-CoV-2 and sPLA2 group IIA (sPLA2-IIA), according to the data obtained by the chemical calculation method. Conclusion: The data obtained in this study is of great importance in terms of guiding experimental studies. It will guide the experimental and clinical studies to be carried out in this field by preventing the loss of time and material.

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